Version 5.4
Homo sapiens Gene: POLR3E
Summary
InnateDB Gene IDBG-19931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR3E
Gene Name polymerase (RNA) III (DNA directed) polypeptide E (80kD)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000058600
Encoded Proteins
IDBP-19933
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
IDBP-19935
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
IDBP-372566
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
IDBP-753247
IDBP-750824
IDBP-746370
IDBP-749892
IDBP-753918
IDBP-754216
IDBP-747887
IDBP-753054
IDBP-807464
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:22297375-22335103
Strand Forward strand
Band p12.2
Transcripts
ENST00000299853 ENSP00000299853
ENST00000359210 ENSP00000352140
ENST00000418581 ENSP00000399254
ENST00000564256
ENST00000564883 ENSP00000456718
ENST00000564209 ENSP00000456967
ENST00000565551 ENSP00000454225
ENST00000563024 ENSP00000456454
ENST00000567022
ENST00000561494 ENSP00000456771
ENST00000569757 ENSP00000454875
ENST00000564750 ENSP00000456526
ENST00000564061
ENST00000563282
ENST00000565117
ENST00000563766
ENST00000565358 ENSP00000454507
ENST00000569787
ENST00000615879 ENSP00000484648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001056 RNA polymerase III activity
GO:0003899 DNA-directed RNA polymerase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006383 transcription from RNA polymerase III promoter
GO:0006385 transcription elongation from RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0010467 gene expression
GO:0032481 positive regulation of type I interferon production
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005813 centrosome
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030880
View Gene Order
ENSBTAG00000018044
Not yet available
Pathways
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_756
RNA Polymerase III Chain Elongation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_1036
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_347
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_71
Gene Expression pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.460298 Hs.596127
RefSeq NM_001258033 NM_001258034 NM_001258035 NM_001258036 NM_018119 XM_005276498 XM_006721063 XM_006726613
HUGO
OMIM
CCDS CCDS10605 CCDS58432 CCDS58433 CCDS58434 CCDS73845
HPRD 15155
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca