Version 5.4
Mus musculus Gene: Rhoa
Summary
InnateDB Gene IDBG-199633.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rhoa
Gene Name ras homolog gene family, member A
Synonyms Arha; Arha1; Arha2
Species Mus musculus
Ensembl Gene ENSMUSG00000007815
Encoded Proteins
IDBP-199635
ras homolog gene family, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067560:
Gene Information
Type Protein coding
Genomic Location Chromosome 9:108306205-108337939
Strand Forward strand
Band F1
Transcripts
ENSMUST00000007959 ENSMUSP00000007959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 100 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 100 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001666 response to hypoxia
GO:0006184 GTP catabolic process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0007519 skeletal muscle tissue development
GO:0008064 regulation of actin polymerization or depolymerization
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0015031 protein transport
GO:0021795 cerebral cortex cell migration
GO:0021861 forebrain radial glial cell differentiation
GO:0030036 actin cytoskeleton organization
GO:0030154 cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030521 androgen receptor signaling pathway
GO:0030838 positive regulation of actin filament polymerization
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032467 positive regulation of cytokinesis
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033688 regulation of osteoblast proliferation
GO:0036089 cleavage furrow formation
GO:0042493 response to drug
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043149 stress fiber assembly
GO:0043200 response to amino acid
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043297 apical junction assembly
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043931 ossification involved in bone maturation
GO:0045471 response to ethanol
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045727 positive regulation of translation
GO:0045785 positive regulation of cell adhesion
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0048812 neuron projection morphogenesis
GO:0050773 regulation of dendrite development
GO:0051384 response to glucocorticoid
GO:0051496 positive regulation of stress fiber assembly
GO:0051924 regulation of calcium ion transport
GO:0060548 negative regulation of cell death
GO:0061383 trabecula morphogenesis
GO:0071803 positive regulation of podosome assembly
GO:2000177 regulation of neural precursor cell proliferation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030496 midbody
GO:0032154 cleavage furrow
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000067560
View Gene Order
ENSBTAG00000004279
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_223625
GPCR downstream signaling pathway
REACT_205300
PI3K/AKT activation pathway
REACT_222662
p75NTR regulates axonogenesis pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_214014
Signaling by Wnt pathway
REACT_254215
Signaling by GPCR pathway
REACT_227951
Signaling by VEGF pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_243939
EPHA-mediated growth cone collapse pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_203657
Axonal growth inhibition (RHOA activation) pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_214043
PCP/CE pathway pathway
REACT_246650
Sema4D induced cell migration and growth-cone collapse pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_196549
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_210090
Rho GTPase cycle pathway
REACT_214242
Axonal growth stimulation pathway
REACT_234744
Sema4D in semaphorin signaling pathway
REACT_248921
Signalling by NGF pathway
REACT_188576
Developmental Biology pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_263034
Semaphorin interactions pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_239484
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_207835
G-protein beta:gamma signalling pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_223974
G beta:gamma signalling through PI3Kgamma pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
mmu04530
Tight junction pathway
mmu04360
Axon guidance pathway
mmu04350
TGF-beta signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04520
Adherens junction pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu04062
Chemokine signaling pathway pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
mmu04972
Pancreatic secretion pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_23
TSH pathway
REACTOME
REACT_1695
GPVI-mediated activation cascade pathway
REACT_12464
PI3K/AKT activation pathway
REACT_13779
Axonal growth stimulation pathway
REACT_13815
Axonal growth inhibition (RHOA activation) pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_120726
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_19266
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_172581
PCP/CE pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_13620
p75NTR regulates axonogenesis pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_19271
Semaphorin interactions pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_12529
Signaling by VEGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_18266
Axon guidance pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_212636
Signaling by Wnt pathway
REACT_231337
EPHA-mediated growth cone collapse pathway
REACT_211252
Sema4D in semaphorin signaling pathway
REACT_221739
Loss of Function of TGFBR1 in Cancer pathway
REACT_217678
Signaling by TGF-beta Receptor Complex pathway
REACT_220609
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_205369
Signaling by GPCR pathway
REACT_204563
p75NTR regulates axonogenesis pathway
REACT_207152
Loss of Function of SMAD4 in Cancer pathway
REACT_218808
Sema4D induced cell migration and growth-cone collapse pathway
REACT_209241
Loss of Function of TGFBR2 in Cancer pathway
REACT_219722
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_227030
Axonal growth inhibition (RHOA activation) pathway
REACT_211150
Rho GTPase cycle pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_211897
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_214353
Signal Transduction pathway
REACT_219098
GPVI-mediated activation cascade pathway
REACT_209608
Signaling by Rho GTPases pathway
REACT_203140
Axon guidance pathway
REACT_211138
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_206800
beta-catenin independent WNT signaling pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_207926
PCP/CE pathway pathway
REACT_214436
GPCR downstream signaling pathway
REACT_217890
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_207066
Signalling by NGF pathway
REACT_226693
Signaling by VEGF pathway
REACT_205384
G alpha (12/13) signalling events pathway
REACT_203136
G-protein beta:gamma signalling pathway
REACT_207908
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_207832
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_218183
p75 NTR receptor-mediated signalling pathway
REACT_259381
EPHB-mediated forward signaling pathway
REACT_225332
PI3K/AKT activation pathway
REACT_221826
Axonal growth stimulation pathway
REACT_216195
Loss of Function of SMAD2/3 in Cancer pathway
REACT_220643
TGFBR1 LBD Mutants in Cancer pathway
REACT_207087
Disease pathway
REACT_209664
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_223905
TGFBR1 KD Mutants in Cancer pathway
REACT_202218
G beta:gamma signalling through PI3Kgamma pathway
REACT_221457
Semaphorin interactions pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa04972
Pancreatic secretion pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
epha_fwdpathway
EPHA forward signaling
txa2pathway
Thromboxane A2 receptor signaling
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pi3kcipathway
Class I PI3K signaling events
s1p_s1p1_pathway
S1P1 pathway
lysophospholipid_pathway
LPA receptor mediated events
il2_1pathway
IL2-mediated signaling events
netrin_pathway
Netrin-mediated signaling events
avb3_integrin_pathway
Integrins in angiogenesis
s1p_s1p2_pathway
S1P2 pathway
ptp1bpathway
Signaling events mediated by PTP1B
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
fak_pathway
Signaling events mediated by focal adhesion kinase
rhoa_reg_pathway
Regulation of RhoA activity
p75ntrpathway
p75(NTR)-mediated signaling
prlsignalingeventspathway
Signaling events mediated by PRL
s1p_s1p5_pathway
S1P5 pathway
s1p_s1p3_pathway
S1P3 pathway
s1p_s1p4_pathway
S1P4 pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
syndecan_4_pathway
Syndecan-4-mediated signaling events
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
thrombin_par4_pathway
PAR4-mediated thrombin signaling events
ret_pathway
Signaling events regulated by Ret tyrosine kinase
shp2_pathway
SHP2 signaling
arf6downstreampathway
Arf6 downstream pathway
rhoa_pathway
RhoA signaling pathway
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
epha2_fwdpathway
EPHA2 forward signaling
aurora_b_pathway
Aurora B signaling
a4b7_pathway
a4b7 Integrin signaling
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
pdgfrbpathway
PDGFR-beta signaling pathway
amb2_neutrophils_pathway
amb2 Integrin signaling
toll_endogenous_pathway
Endogenous TLR signaling
ncadherinpathway
N-cadherin signaling events
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt Q9QUI0
TrEMBL Q4VAE6
UniProt Splice Variant
Entrez Gene 11848
UniGene Mm.471953
RefSeq NM_016802 XM_006511633
OMIM
CCDS CCDS23521
HPRD
IMGT
MGI ID MGI:1096342
MGI Symbol Rhoa
EMBL AF014371 AF178958 AF178959 AF178960 AF178961 AK077606 AK083624 AK150475 AK152629 AK172051 BC068115 BC096423 CH466560 JN971019
GenPept AAC23710 AAD52675 AAD52676 AAD52677 AAD52678 AAH68115 AAH96423 AFR23588 BAC36896 BAC38971 BAE29592 BAE31372 BAE42800 EDL21278 EDL21279
RNA Seq Atlas 11848

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca