InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pink1

Summary

InnateDB Gene

IDBG-199773.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pink1

Gene Name

PTEN induced putative kinase 1

Synonyms

1190006F07Rik; AU042772; AW557854; BRPK; mFLJ00387

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028756

Encoded Proteins

IDBP-199775

PTEN induced putative kinase 1

IDBP-270063

PTEN induced putative kinase 1

IDBP-270065

PTEN induced putative kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158828:
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:138313409-138326307

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030536	ENSMUSP00000030536
ENSMUST00000105817	ENSMUSP00000101443
ENSMUST00000105816	ENSMUSP00000101442

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0010857	calcium-dependent protein kinase activity
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031625	ubiquitin protein ligase binding
GO:0055131	C3HC4-type RING finger domain binding

Biological Process

GO:0000422	mitochondrion degradation
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0016567	protein ubiquitination
GO:0018105	peptidyl-serine phosphorylation
GO:0031396	regulation of protein ubiquitination
GO:0032226	positive regulation of synaptic transmission, dopaminergic
GO:0033603	positive regulation of dopamine secretion
GO:0033605	positive regulation of catecholamine secretion
GO:0035556	intracellular signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254	regulation of protein complex assembly
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097237	cellular response to toxic substance
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000158828

View Gene Order

ENSBTAG00000006084

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05012

Parkinson's disease pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05012

Parkinson's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.18539

RefSeq

NM_026880

OMIM

CCDS

CCDS18825

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas