InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acta1

Summary

InnateDB Gene

IDBG-199779.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acta1

Gene Name

actin, alpha 1, skeletal muscle

Synonyms

AA959943; Acta-2; Acts; Actsk-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031972

Encoded Proteins

IDBP-199781

actin, alpha 1, skeletal muscle

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143632:
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:123891767-123894736

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034453

ENSMUSP00000034453

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0009612	response to mechanical stimulus
GO:0009991	response to extracellular stimulus
GO:0010226	response to lithium ion
GO:0016049	cell growth
GO:0030240	skeletal muscle thin filament assembly
GO:0043503	skeletal muscle fiber adaptation
GO:0048545	response to steroid hormone
GO:0048741	skeletal muscle fiber development

Cellular Component

GO:0001725	stress fiber
GO:0005615	extracellular space
GO:0005865	striated muscle thin filament
GO:0005884	actin filament
GO:0015629	actin cytoskeleton
GO:0030017	sarcomere
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle