Mus musculus Gene: Qars
Summary
InnateDB Gene IDBG-200091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Qars
Gene Name glutaminyl-tRNA synthetase
Synonyms 1110018N24Rik; 1200016L19Rik; C80286; GLNRS
Species Mus musculus
Ensembl Gene ENSMUSG00000032604
Encoded Proteins
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172053:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:108508005-108515941
Strand Forward strand
Band F2
Transcripts
ENSMUST00000006838 ENSMUSP00000006838
ENSMUST00000154324
ENSMUST00000144253
ENSMUST00000141201
ENSMUST00000134939 ENSMUSP00000122918
ENSMUST00000123316 ENSMUSP00000115967
ENSMUST00000137980
ENSMUST00000131005
ENSMUST00000141903 ENSMUSP00000121146
ENSMUST00000154311
ENSMUST00000141780
ENSMUST00000136293
ENSMUST00000137655
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.
Predicted by orthology
Total 56 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004819 glutamine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006425 glutaminyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Mitochondrial tRNA aminoacylation pathway
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
Glutamate Glutamine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.272427 Mm.398165 Mm.468458
RefSeq NM_001168270 NM_133794
OMIM
CCDS CCDS23530 CCDS52926
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas