Version 5.4
Homo sapiens Gene: BCL2L14
Summary
InnateDB Gene IDBG-20014.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL2L14
Gene Name BCL2-like 14 (apoptosis facilitator)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121380
Encoded Proteins
IDBP-20016
BCL2-like 14 (apoptosis facilitator)
IDBP-20018
BCL2-like 14 (apoptosis facilitator)
IDBP-20020
BCL2-like 14 (apoptosis facilitator)
IDBP-237662
BCL2-like 14 (apoptosis facilitator)
IDBP-485256
BCL2-like 14 (apoptosis facilitator)
IDBP-473672
BCL2-like 14 (apoptosis facilitator)
IDBP-716948
IDBP-716938
IDBP-718163
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:12049844-12211084
Strand Forward strand
Band p13.2
Transcripts
ENST00000308721 ENSP00000309132
ENST00000266434 ENSP00000266434
ENST00000298566 ENSP00000298566
ENST00000396367 ENSP00000379653
ENST00000464885 ENSP00000417223
ENST00000484949
ENST00000461264 ENSP00000419617
ENST00000479717
ENST00000466531
ENST00000545463
ENST00000589718 ENSP00000467086
ENST00000586576 ENSP00000466693
ENST00000591235
ENST00000588270 ENSP00000465663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0006915 apoptotic process
GO:0042981 regulation of apoptotic process
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0043229 intracellular organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030200
View Gene Order
ENSBTAG00000047225
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.210343 Hs.733298 Hs.734567
RefSeq NM_030766 NM_138722 NM_138723
HUGO
OMIM
CCDS CCDS8645 CCDS8646
HPRD 05841
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca