Version 5.4
Mus musculus Gene: Usp33
Summary
InnateDB Gene IDBG-200159.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp33
Gene Name ubiquitin specific peptidase 33
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025437
Encoded Proteins
IDBP-200163
ubiquitin specific peptidase 33
IDBP-400328
ubiquitin specific peptidase 33
IDBP-531965
ubiquitin specific peptidase 33
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077254:
This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:152346478-152393612
Strand Forward strand
Band H3
Transcripts
ENSMUST00000026507 ENSMUSP00000026507
ENSMUST00000117492 ENSMUSP00000113265
ENSMUST00000123237 ENSMUSP00000117590
ENSMUST00000142969
ENSMUST00000138575
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006897 endocytosis
GO:0007411 axon guidance
GO:0008152 metabolic process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0051298 centrosome duplication
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005813 centrosome
GO:0044297 cell body
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000077254
View Gene Order
ENSBTAG00000020761
Not yet available
Cross-References
SwissProt Q8R5K2
TrEMBL
UniProt Splice Variant
Entrez Gene 170822
UniGene Mm.431824
RefSeq NM_001076676 NM_001252486 NM_133247 XM_006501079
OMIM
CCDS CCDS57261 CCDS17918
HPRD
IMGT
MGI ID MGI:2159711
MGI Symbol Usp33
EMBL AF383174 AK143844 BC005506 BC031366 BC089315
GenPept AAH05506 AAH31366 AAH89315 AAL78316 BAE25565
RNA Seq Atlas 170822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca