Mus musculus Gene: Impdh2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-200174.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Impdh2 | ||||||||||||||||||||||
Gene Name | inosine 5'-phosphate dehydrogenase 2 | ||||||||||||||||||||||
Synonyms | IMPD | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000062867 | ||||||||||||||||||||||
Encoded Proteins |
inosine 5'-phosphate dehydrogenase 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
Impdh2 proteins are rapidly recruited to the lipid raft of monocytes after lipopeptide stimulation, and play an essential role in the negative regulation of Tlr2 signalling by modulating PI3K activity. (Demonstrated in human)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] IMPDH2 proteins are rapidly recruited to the lipid raft of monocytes after lipopeptide stimulation, and play an essential role in the negative regulation of TLR2 signalling by modulating PI3K activity.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178035:
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008] This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5\'-monophosphate into xanthine-5\'-monophosphate, which is then converted into guanosine-5\'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 9:108560534-108565519 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | F2 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Purine metabolism pathway
Metabolism pathway
Purine ribonucleoside monophosphate biosynthesis pathway
Metabolism of nucleotides pathway
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KEGG |
Purine metabolism pathway
Drug metabolism pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Purine ribonucleoside monophosphate biosynthesis pathway
Metabolism of nucleotides pathway
Purine metabolism pathway
Metabolism pathway
Metabolism of nucleotides pathway
Purine metabolism pathway
Metabolism pathway
Purine ribonucleoside monophosphate biosynthesis pathway
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KEGG |
Purine metabolism pathway
Drug metabolism pathway
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INOH |
Purine nucleotides nucleosides metabolism pathway
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PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P24547 | ||||||||||||||||||||||
TrEMBL | Q3UAT9 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 23918 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_011830 XM_001478153 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS40768 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:109367 | ||||||||||||||||||||||
MGI Symbol | Impdh2 | ||||||||||||||||||||||
EMBL | AK150713 AK151233 AK152691 AK159822 AK160569 AK166667 AK169129 AK169788 BC010314 BC052671 CH466560 M33934 M98333 | ||||||||||||||||||||||
GenPept | AAA20181 AAA39311 AAH10314 AAH52671 BAE29791 BAE30225 BAE31422 BAE35402 BAE35879 BAE38929 BAE40908 BAE41367 EDL21302 | ||||||||||||||||||||||
RNA Seq Atlas | 100042069 23918 | ||||||||||||||||||||||