InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nbl1

Summary

InnateDB Gene

IDBG-200197.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nbl1

Gene Name

neuroblastoma, suppression of tumorigenicity 1

Synonyms

D4H1S1733E; DAN; Dana; NO3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041120

Encoded Proteins

IDBP-200199

neuroblastoma, suppression of tumorigenicity 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158747:
This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The read-through transcripts produce at least two proteins, each of which share identity with proteins translated from the downstream neuroblastoma suppressor of tumorigenicity 1 locus. [provided by RefSeq, Feb 2011] This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream chromosome 1 open reading frame 151 locus (GeneID 440574) have been observed.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:139082284-139092993

Strand

Reverse strand

Band

Transcripts

ENSMUST00000042844	ENSMUSP00000045608
ENSMUST00000132940
ENSMUST00000132900

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016015	morphogen activity
GO:0036122	BMP binding

Biological Process

GO:0007399	nervous system development
GO:0030514	negative regulation of BMP signaling pathway
GO:0035582	sequestering of BMP in extracellular matrix
GO:0045666	positive regulation of neuron differentiation
GO:0048263	determination of dorsal identity
GO:0048812	neuron projection morphogenesis
GO:0090027	negative regulation of monocyte chemotaxis

Cellular Component

GO:0005576

extracellular region

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000158747

View Gene Order

ENSBTAG00000005140

Not yet available

Cross-References

SwissProt

Q61477

TrEMBL

UniProt Splice Variant

Entrez Gene

17965

UniGene

Mm.9404

RefSeq

NM_008675 XM_006538623 XM_006538624 XM_006538625 XM_006538626

OMIM

CCDS

CCDS18839

HPRD

IMGT

MGI ID

MGI:104591

MGI Symbol

Nbl1

EMBL

AK133787 AK146535 AK158008 AL805923 BC099856 BC099857 BC099858 BC107810 CH466615 D50263

GenPept

AAH99856 AAH99857 AAH99858 AAI07811 BAA08817 BAE21841 BAE27241 BAE34315 CAM26546 EDL13294

RNA Seq Atlas

17965