Version 5.4
Homo sapiens Gene: YY1
Summary
InnateDB Gene IDBG-20038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YY1
Gene Name YY1 transcription factor
Synonyms DELTA; INO80S; NF-E1; UCRBP; YIN-YANG-1
Species Homo sapiens
Ensembl Gene ENSG00000100811
Encoded Proteins
IDBP-20040
YY1 transcription factor
IDBP-585304
YY1 transcription factor
IDBP-584922
YY1 transcription factor
IDBP-592988
YY1 transcription factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22065573
YY1 negatively regulates TLR3-induced expression of IFN-beta and acts downstream of TLR3 to limit the level and duration of anti-viral response.
InnateDB Annotation from Orthologs
Summary
PMID 22065573
[Mus musculus] Yy1 negatively regulates TLR3-induced expression of IFN-beta and acts downstream of TLR3 to limit the level and duration of the anti-viral response. (Demonstrated in human)
Entrez Gene
Summary YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:100238298-100282792
Strand Forward strand
Band q32.2
Transcripts
ENST00000262238 ENSP00000262238
ENST00000554371 ENSP00000451329
ENST00000553625 ENSP00000452140
ENST00000554804 ENSP00000452225
ENST00000554579
ENST00000623799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 202 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 202 [view]
Protein-Protein 182 [view]
Protein-DNA 14 [view]
Protein-RNA 4 [view]
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000400 four-way junction DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000724 double-strand break repair via homologous recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006403 RNA localization
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0009952 anterior/posterior pattern specification
GO:0010225 response to UV-C
GO:0030154 cell differentiation
GO:0034644 cellular response to UV
GO:0034696 response to prostaglandin F
GO:0045087 innate immune response (InnateDB)
GO:0048593 camera-type eye morphogenesis
GO:0051276 chromosome organization
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0016363 nuclear matrix
GO:0031011 Ino80 complex
GO:0031519 PcG protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021264
View Gene Order
ENSBTAG00000020819
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
REACTOME
KEGG
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
hdac_classi_pathway
Signaling events mediated by HDAC Class I
hes_heypathway
Notch-mediated HES/HEY network
p53regulationpathway
p53 pathway
e2f_pathway
E2F transcription factor network
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL G3V3M8
UniProt Splice Variant
Entrez Gene 7528
UniGene Hs.388927 Hs.603118 Hs.708121 Hs.708383 Hs.708987 Hs.740171
RefSeq NM_003403
HUGO HGNC:12856
OMIM 600013
CCDS CCDS9957
HPRD 02482
IMGT
EMBL AL157871
GenPept
RNA Seq Atlas 102466730 7528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca