InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nrp1

Summary

InnateDB Gene

IDBG-201088.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrp1

Gene Name

neuropilin 1

Synonyms

C530029I03; NP-1; NPN-1; Npn1; Nrp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025810

Encoded Proteins

IDBP-201090

neuropilin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099250:
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:128359073-128505462

Strand

Forward strand

Band

Transcripts

ENSMUST00000026917

ENSMUSP00000026917

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017154	semaphorin receptor activity
GO:0019838	growth factor binding
GO:0038085	vascular endothelial growth factor binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001764	neuron migration
GO:0002040	sprouting angiogenesis
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0007507	heart development
GO:0008045	motor neuron axon guidance
GO:0009611	response to wounding
GO:0009887	organ morphogenesis
GO:0016358	dendrite development
GO:0016477	cell migration
GO:0021612	facial nerve structural organization
GO:0021636	trigeminal nerve morphogenesis
GO:0021637	trigeminal nerve structural organization
GO:0021675	nerve development
GO:0021785	branchiomotor neuron axon guidance
GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0030517	negative regulation of axon extension
GO:0031290	retinal ganglion cell axon guidance
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0035767	endothelial cell chemotaxis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0038190	VEGF-activated neuropilin signaling pathway
GO:0043524	negative regulation of neuron apoptotic process
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0048485	sympathetic nervous system development
GO:0048666	neuron development
GO:0048841	regulation of axon extension involved in axon guidance
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0048844	artery morphogenesis
GO:0048846	axon extension involved in axon guidance
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0060385	axonogenesis involved in innervation
GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching
GO:0060978	angiogenesis involved in coronary vascular morphogenesis
GO:0060980	cell migration involved in coronary vasculogenesis
GO:0060982	coronary artery morphogenesis
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:0061441	renal artery morphogenesis
GO:0061549	sympathetic ganglion development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071526	semaphorin-plexin signaling pathway
GO:0071679	commissural neuron axon guidance
GO:0090259	regulation of retinal ganglion cell axon guidance
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1901166	neural crest cell migration involved in autonomic nervous system development
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance
GO:1902336	positive regulation of retinal ganglion cell axon guidance
GO:1902378	VEGF-activated neuropilin signaling pathway involved in axon guidance
GO:1902946	protein localization to early endosome
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005883	neurofilament
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030426	growth cone
GO:0043025	neuronal cell body
GO:0097443	sorting endosome