Version 5.4
Mus musculus Gene: Prkce
Summary
InnateDB Gene IDBG-201164.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prkce
Gene Name protein kinase C, epsilon
Synonyms 5830406C15Rik; PKC[e]; Pkce; PKCepsilon; R75156
Species Mus musculus
Ensembl Gene ENSMUSG00000045038
Encoded Proteins
IDBP-201166
protein kinase C, epsilon
IDBP-201170
protein kinase C, epsilon
IDBP-787780
protein kinase C, epsilon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19150425
[Homo sapiens] Following TNF stimulation, PRKCE phosphorylates TRAF2 leading to CHUK (IKK alpha) and IKBKB (IKK beta) recruitment to the TNF receptor
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171132:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:86167785-86657919
Strand Forward strand
Band E4
Transcripts
ENSMUST00000097275 ENSMUSP00000094874
ENSMUST00000097274 ENSMUSP00000094873
ENSMUST00000142003 ENSMUSP00000138615
ENSMUST00000150486
ENSMUST00000136986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004699 calcium-independent protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008047 enzyme activator activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0030546 receptor activator activity
GO:0035276 ethanol binding
GO:0046872 metal ion binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0002281 macrophage activation involved in immune response
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007635 chemosensory behavior
GO:0010634 positive regulation of epithelial cell migration
GO:0010763 positive regulation of fibroblast migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0019216 regulation of lipid metabolic process
GO:0030838 positive regulation of actin filament polymerization
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0032467 positive regulation of cytokinesis
GO:0035556 intracellular signal transduction
GO:0035641 locomotory exploration behavior
GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway
GO:0043085 positive regulation of catalytic activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043278 response to morphine
GO:0043410 positive regulation of MAPK cascade
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050996 positive regulation of lipid catabolic process
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051301 cell division
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070257 positive regulation of mucus secretion
GO:0071361 cellular response to ethanol
GO:0071456 cellular response to hypoxia
GO:0090303 positive regulation of wound healing
GO:2000273 positive regulation of receptor activity
GO:2001031 positive regulation of cellular glucuronidation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171132
View Gene Order
ENSBTAG00000020614
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_188190
PLCG1 events in ERBB2 signaling pathway
REACT_223625
GPCR downstream signaling pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_210240
Role of phospholipids in phagocytosis pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_263607
PLC-gamma1 signalling pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_236516
EGFR interacts with phospholipase C-gamma pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_219232
Effects of PIP2 hydrolysis pathway
REACT_242976
Signaling by EGFR pathway
REACT_258013
G alpha (z) signalling events pathway
REACT_230708
Phospholipase C-mediated cascade pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_248921
Signalling by NGF pathway
REACT_263353
Signaling by PDGF pathway
REACT_188269
DAG and IP3 signaling pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04530
Tight junction pathway
mmu04930
Type II diabetes mellitus pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04270
Vascular smooth muscle contraction pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
NetPath_12
BCR pathway
NetPath_22
Leptin pathway
REACTOME
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04530
Tight junction pathway
hsa04930
Type II diabetes mellitus pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
lysophospholipid_pathway
LPA receptor mediated events
il2_1pathway
IL2-mediated signaling events
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
cdc42_pathway
CDC42 signaling events
lpa4_pathway
LPA4-mediated signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt P16054
TrEMBL
UniProt Splice Variant
Entrez Gene 18754
UniGene Mm.24614 Mm.400923 Mm.450712
RefSeq NM_011104 XM_006523833
OMIM
CCDS CCDS29008
HPRD
IMGT
MGI ID MGI:97599
MGI Symbol Prkce
EMBL AF028009 AF325507
GenPept AAB84189 AAG53692
RNA Seq Atlas 18754

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca