Version 5.4
Mus musculus Gene: Calm2
Summary
InnateDB Gene IDBG-201414.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Calm2
Gene Name calmodulin 2
Synonyms 1500001E21Rik; AI256814; AI327027; AI461935; AL024000; AL024017; Calm; CaM; CaMA; R75142
Species Mus musculus
Ensembl Gene ENSMUSG00000036438
Encoded Proteins
IDBP-201416
calmodulin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:87433412-87446935
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000040440 ENSMUSP00000048857
ENSMUST00000143965
ENSMUST00000150137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008179 adenylate cyclase binding
GO:0019904 protein domain specific binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0031432 titin binding
GO:0031800 type 3 metabotropic glutamate receptor binding
GO:0031996 thioesterase binding
GO:0031997 N-terminal myristoylation domain binding
GO:0043274 phospholipase binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044325 ion channel binding
GO:0048306 calcium-dependent protein binding
GO:0050998 nitric-oxide synthase binding
GO:0072542 protein phosphatase activator activity
Biological Process
GO:0001975 response to amphetamine
GO:0002027 regulation of heart rate
GO:0005513 detection of calcium ion
GO:0007190 activation of adenylate cyclase activity
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019722 calcium-mediated signaling
GO:0021762 substantia nigra development
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0032465 regulation of cytokinesis
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0035307 positive regulation of protein dephosphorylation
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051412 response to corticosterone
GO:0051592 response to calcium ion
GO:0055117 regulation of cardiac muscle contraction
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity
GO:1901841 regulation of high voltage-gated calcium channel activity
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0005886 plasma membrane
GO:0030017 sarcomere
GO:0030426 growth cone
GO:0034704 calcium channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_199047
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_239142
Innate Immune System pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_188190
PLCG1 events in ERBB2 signaling pathway
REACT_188194
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_214014
Signaling by Wnt pathway
REACT_204801
eNOS activation and regulation pathway
REACT_254215
Signaling by GPCR pathway
REACT_209837
Membrane Trafficking pathway
REACT_198684
Ionotropic activity of Kainate Receptors pathway
REACT_198685
Activation of Kainate Receptors upon glutamate binding pathway
REACT_221264
eNOS activation pathway
REACT_259326
Ca-dependent events pathway
REACT_227951
Signaling by VEGF pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_203795
DARPP-32 events pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_198694
Activation of Ca-permeable Kainate Receptor pathway
REACT_245086
VEGFR2 mediated cell proliferation pathway
REACT_235059
Smooth Muscle Contraction pathway
REACT_263607
PLC-gamma1 signalling pathway
REACT_261601
Glucose metabolism pathway
REACT_188937
Metabolism pathway
REACT_198244
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_198246
CREB phosphorylation through the activation of Ras pathway
REACT_198248
CREB phosphorylation through the activation of CaMKII pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_236516
EGFR interacts with phospholipase C-gamma pathway
REACT_218233
Post NMDA receptor activation events pathway
REACT_216520
CaMK IV-mediated phosphorylation of CREB pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_215503
CREB phosphorylation through the activation of CaMKK pathway
REACT_240702
CaM pathway pathway
REACT_262759
Muscle contraction pathway
REACT_242976
Signaling by EGFR pathway
REACT_256123
Glycogen breakdown (glycogenolysis) pathway
REACT_230708
Phospholipase C-mediated cascade pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_227001
Cam-PDE 1 activation pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_221970
Ca2+ pathway pathway
REACT_188202
FCERI mediated Ca+2 mobilization pathway
REACT_205251
Transcriptional activation of mitochondrial biogenesis pathway
REACT_218249
Activation of CaMK IV pathway
REACT_203949
Glycogen storage diseases pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_259290
Neuronal System pathway
REACT_188269
DAG and IP3 signaling pathway
REACT_208364
Metabolism of nitric oxide pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242845
Opioid Signalling pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_215587
Calmodulin induced events pathway
REACT_188257
Signal Transduction pathway
REACT_196476
Inositol phosphate metabolism pathway
REACT_196473
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_211261
Mitochondrial biogenesis pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_242456
Signaling by FGFR pathway
REACT_214376
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_253342
PLC beta mediated events pathway
REACT_248370
G-protein mediated events pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
REACT_248571
Metabolism of carbohydrates pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04740
Olfactory transduction pathway
mmu04910
Insulin signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04916
Melanogenesis pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu04912
GnRH signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu05214
Glioma pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04114
Oocyte meiosis pathway
mmu04744
Phototransduction pathway
mmu04971
Gastric acid secretion pathway
mmu04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.426871 Mm.466629
RefSeq NM_007589 XM_006523539
OMIM
CCDS CCDS37716
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca