Version 5.4
Mus musculus Gene: Epcam
Summary
InnateDB Gene IDBG-201437.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Epcam
Gene Name epithelial cell adhesion molecule
Synonyms CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1; GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1
Species Mus musculus
Ensembl Gene ENSMUSG00000045394
Encoded Proteins
IDBP-201439
epithelial cell adhesion molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119888:
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:87635979-87651106
Strand Forward strand
Band E4
Transcripts
ENSMUST00000053577 ENSMUSP00000061935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0001657 ureteric bud development
GO:0008284 positive regulation of cell proliferation
GO:0023019 signal transduction involved in regulation of gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048863 stem cell differentiation
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000648 positive regulation of stem cell proliferation
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119888
View Gene Order
ENSBTAG00000006474
Not yet available
Cross-References
SwissProt Q99JW5
TrEMBL Q8CG12
UniProt Splice Variant
Entrez Gene 17075
UniGene Mm.4259 Mm.476268
RefSeq NM_008532
OMIM
CCDS CCDS29018
HPRD
IMGT
MGI ID MGI:106653
MGI Symbol Epcam
EMBL AJ489452 AJ489453 AJ489454 AJ489455 AK145752 AK167182 BC005618 BC094465 M76124
GenPept AAA37543 AAH05618 AAH94465 BAE26627 BAE39317 CAD33710
RNA Seq Atlas 17075

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca