Version 5.4
Mus musculus Gene: Fasl
Summary
InnateDB Gene IDBG-201576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fasl
Gene Name Fas ligand (TNF superfamily, member 6)
Synonyms APT1LG1; CD178; CD95-L; CD95L; Fas-L; Faslg; gld; Tnfsf6
Species Mus musculus
Ensembl Gene ENSMUSG00000000817
Encoded Proteins
IDBP-201578
Fas ligand (TNF superfamily, member 6)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117560:
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161780691-161788495
Strand Reverse strand
Band H2.1
Transcripts
ENSMUST00000000834 ENSMUSP00000000834
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005123 death receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006925 inflammatory cell apoptotic process
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0016525 negative regulation of angiogenesis
GO:0030644 cellular chloride ion homeostasis
GO:0032496 response to lipopolysaccharide
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043525 positive regulation of neuron apoptotic process
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0046666 retinal cell programmed cell death
GO:0048388 endosomal lumen acidification
GO:0070231 T cell apoptotic process
GO:0070266 necroptotic process
GO:0070848 response to growth factor
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097527 necroptotic signaling pathway
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005901 caveola
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0043202 lysosomal lumen
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117560
View Gene Order
ENSBTAG00000032808
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_243608
Dimerization of procaspase-8 pathway
REACT_241657
Caspase-8 activation by cleavage pathway
REACT_263715
FasL/ CD95L signaling pathway
REACT_257735
Death Receptor Signalling pathway
REACT_215122
Regulation by c-FLIP pathway
REACT_259850
Extrinsic Pathway for Apoptosis pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04940
Type I diabetes mellitus pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04010
MAPK signaling pathway pathway
mmu04210
Apoptosis pathway
mmu05330
Allograft rejection pathway
mmu05332
Graft-versus-host disease pathway
mmu05320
Autoimmune thyroid disease pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu05200
Pathways in cancer pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
mmu05143
African trypanosomiasis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
INOH website
Fas signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_900
FasL/ CD95L signaling pathway
REACT_1059
Extrinsic Pathway for Apoptosis pathway
REACT_578
Apoptosis pathway
REACT_1619
Death Receptor Signalling pathway
KEGG
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04940
Type I diabetes mellitus pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05332
Graft-versus-host disease pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05143
African trypanosomiasis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
INOH website
Fas signaling pathway pathway
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
caspase_pathway
Caspase Cascade in Apoptosis
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
foxopathway
FoxO family signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt P41047
TrEMBL Q544E9
UniProt Splice Variant
Entrez Gene 14103
UniGene Mm.3355
RefSeq NM_010177 XM_006496653 XM_006496654
OMIM
CCDS CCDS15418
HPRD
IMGT
MGI ID MGI:99255
MGI Symbol Fasl
EMBL AF119335 AK040139 AK141268 CH466520 S76752 U06948 U10984 U58995
GenPept AAA17800 AAA19778 AAB02915 AAB33780 AAD52106 BAC30520 BAE24625 EDL39311
RNA Seq Atlas 14103

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca