Version 5.4
Mus musculus Gene: Epb4
Summary
InnateDB Gene IDBG-201705.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Epb4
Gene Name erythrocyte protein band 4.2
Synonyms Epb42
Species Mus musculus
Ensembl Gene ENSMUSG00000023216
Encoded Proteins
IDBP-201707
erythrocyte protein band 4.2
IDBP-201709
erythrocyte protein band 4.2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166947:
Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:121017891-121037072
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000102490 ENSMUSP00000099548
ENSMUST00000023987 ENSMUSP00000023987
ENSMUST00000124703
ENSMUST00000147444
ENSMUST00000145812
ENSMUST00000128360
ENSMUST00000152217
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0008360 regulation of cell shape
GO:0018149 peptide cross-linking
GO:0020027 hemoglobin metabolic process
GO:0043249 erythrocyte maturation
GO:0048536 spleen development
GO:0050801 ion homeostasis
GO:0055072 iron ion homeostasis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166947
View Gene Order
ENSBTAG00000011439
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.240051 Mm.395222
RefSeq NM_013513 XM_006498727
OMIM
CCDS CCDS16631
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca