InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lhcgr

Summary

InnateDB Gene

IDBG-201721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lhcgr

Gene Name

luteinizing hormone/choriogonadotropin receptor

Synonyms

Gpcr19-rs1; LH-R; Lhr

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024107

Encoded Proteins

IDBP-201723

luteinizing hormone/choriogonadotropin receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138039:
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:88741549-88791976

Strand

Reverse strand

Band

Transcripts

ENSMUST00000024916

ENSMUSP00000024916

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004964	luteinizing hormone receptor activity
GO:0035472	choriogonadotropin hormone receptor activity
GO:0038106	choriogonadotropin hormone binding

Biological Process

GO:0001541	ovarian follicle development
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0022602	ovulation cycle process
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0042700	luteinizing hormone signaling pathway
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0046544	development of secondary male sexual characteristics
GO:0060065	uterus development
GO:0071371	cellular response to gonadotropin stimulus
GO:0072520	seminiferous tubule development
GO:0090030	regulation of steroid hormone biosynthetic process