InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: P2ry6

Summary

InnateDB Gene

IDBG-201747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2ry6

Gene Name

pyrimidinergic receptor P2Y, G-protein coupled, 6

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000048779

Encoded Proteins

IDBP-201749

pyrimidinergic receptor P2Y, G-protein coupled, 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171631:
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:100937638-100964391

Strand

Reverse strand

Band

Transcripts

ENSMUST00000060174

ENSMUSP00000055697

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0019103	pyrimidine nucleotide binding
GO:0045028	G-protein coupled purinergic nucleotide receptor activity
GO:0045029	UDP-activated nucleotide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0014911	positive regulation of smooth muscle cell migration
GO:0030321	transepithelial chloride transport
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway