InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trp53bp1

Summary

InnateDB Gene

IDBG-201919.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trp53bp1

Gene Name

transformation related protein 53 binding protein 1

Synonyms

53BP1; m53BP1; p53BP1; Tp53bp1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000043909

Encoded Proteins

IDBP-259802

transformation related protein 53 binding protein 1

IDBP-259804

transformation related protein 53 binding protein 1

IDBP-541744

transformation related protein 53 binding protein 1

IDBP-540802

transformation related protein 53 binding protein 1

IDBP-539579

transformation related protein 53 binding protein 1

IDBP-538082

transformation related protein 53 binding protein 1

IDBP-537045

transformation related protein 53 binding protein 1

IDBP-536328

transformation related protein 53 binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067369:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:121193281-121271407

Strand

Reverse strand

Band

Transcripts

ENSMUST00000110648	ENSMUSP00000106278
ENSMUST00000110647	ENSMUSP00000106277
ENSMUST00000135890
ENSMUST00000147540	ENSMUSP00000119793
ENSMUST00000147554
ENSMUST00000154426	ENSMUSP00000117548
ENSMUST00000132812
ENSMUST00000124554	ENSMUSP00000122629
ENSMUST00000124411
ENSMUST00000140582
ENSMUST00000156493
ENSMUST00000131245	ENSMUSP00000114457
ENSMUST00000142400	ENSMUSP00000119425
ENSMUST00000124031
ENSMUST00000129752	ENSMUSP00000120451
ENSMUST00000136617
ENSMUST00000131426
ENSMUST00000140285
ENSMUST00000124060

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 111 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	111 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0002039	p53 binding
GO:0003684	damaged DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035064	methylated histone binding
GO:0042162	telomeric DNA binding

Biological Process

GO:0006281	DNA repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000776	kinetochore
GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000067369

View Gene Order

ENSBTAG00000021304

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_97

Recruitment of repair and signaling proteins to double-strand breaks pathway

REACT_1874

Homologous Recombination Repair pathway

REACT_2054

Double-Strand Break Repair pathway

REACT_1587

Homologous recombination repair of replication-independent double-strand breaks pathway

REACT_216

DNA Repair pathway

KEGG

INOH

PID NCI

atm_pathway

ATM pathway

Cross-References

SwissProt

TrEMBL

F6VCK5

UniProt Splice Variant

Entrez Gene

27223

UniGene

Mm.215389 Mm.428366 Mm.481841

RefSeq

NM_001290830 NM_013735 XM_006499661 XM_006499662 XM_006499665 XM_006499666 XM_006499667 XM_006499668

OMIM

CCDS

CCDS50684 CCDS71125

HPRD

IMGT

MGI ID

MGI:1351320

MGI Symbol

Trp53bp1

EMBL

AL929059

GenPept

RNA Seq Atlas

27223