InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ltf

Summary

InnateDB Gene

IDBG-202627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ltf

Gene Name

lactotransferrin

Synonyms

Csp82; Lf; MMS10R; Ms10r

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032496

Encoded Proteins

IDBP-202629

lactotransferrin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000012223:
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:111019292-111042766

Strand

Forward strand

Band

Transcripts

ENSMUST00000035077

ENSMUSP00000035077

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008199	ferric iron binding
GO:0008201	heparin binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0001503	ossification
GO:0001817	regulation of cytokine production
GO:0001895	retina homeostasis
GO:0002227	innate immune response in mucosa
GO:0006508	proteolysis
GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0019731	antibacterial humoral response
GO:0019732	antifungal humoral response
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032680	regulation of tumor necrosis factor production
GO:0033690	positive regulation of osteoblast proliferation
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045669	positive regulation of osteoblast differentiation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060349	bone morphogenesis
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:1900159	positive regulation of bone mineralization involved in bone maturation
GO:1900229	negative regulation of single-species biofilm formation in or on host organism
GO:1902732	positive regulation of chondrocyte proliferation
GO:2000308	negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2001205	negative regulation of osteoclast development

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030141	secretory granule
GO:0042581	specific granule
GO:0070062	extracellular vesicular exosome