InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gpd1l

Summary

InnateDB Gene

IDBG-203718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpd1l

Gene Name

glycerol-3-phosphate dehydrogenase 1-like

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000050627

Encoded Proteins

IDBP-203720

glycerol-3-phosphate dehydrogenase 1-like

IDBP-538234

glycerol-3-phosphate dehydrogenase 1-like

IDBP-537660

glycerol-3-phosphate dehydrogenase 1-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152642:
The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:114899341-114933987

Strand

Reverse strand

Band

Transcripts

ENSMUST00000084853	ENSMUSP00000081913
ENSMUST00000146623	ENSMUSP00000117509
ENSMUST00000129305	ENSMUSP00000123212
ENSMUST00000146266

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0017080	sodium channel regulator activity
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding
GO:0050662	coenzyme binding
GO:0051287	NAD binding

Biological Process

GO:0002027	regulation of heart rate
GO:0005975	carbohydrate metabolic process
GO:0006072	glycerol-3-phosphate metabolic process
GO:0006734	NADH metabolic process
GO:0010765	positive regulation of sodium ion transport
GO:0019674	NAD metabolic process
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0046168	glycerol-3-phosphate catabolic process
GO:0055114	oxidation-reduction process
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0086005	ventricular cardiac muscle cell action potential
GO:0090038	negative regulation of protein kinase C signaling
GO:2000010	positive regulation of protein localization to cell surface
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009331	glycerol-3-phosphate dehydrogenase complex
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome