InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Suz12

Summary

InnateDB Gene

IDBG-203783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Suz12

Gene Name

suppressor of zeste 12 homolog (Drosophila)

Synonyms

2610028O16Rik; AI195385; AU016842; AW536442; D11Ertd530e; mKIAA0160

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017548

Encoded Proteins

IDBP-203785

suppressor of zeste 12 homolog (Drosophila)

IDBP-626150

suppressor of zeste 12 homolog (Drosophila)

IDBP-626151

suppressor of zeste 12 homolog (Drosophila)

IDBP-626152

suppressor of zeste 12 homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:79993106-80034123

Strand

Forward strand

Band

Transcripts

ENSMUST00000017692	ENSMUSP00000017692
ENSMUST00000132312
ENSMUST00000148140
ENSMUST00000126091	ENSMUSP00000129070
ENSMUST00000144188	ENSMUSP00000128945
ENSMUST00000163272	ENSMUSP00000126932

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	40 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0042054	histone methyltransferase activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0016571	histone methylation
GO:0016574	histone ubiquitination
GO:0045596	negative regulation of cell differentiation