Mus musculus Gene: Mdh2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-204115.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Mdh2 | ||||||||||||||||||||||
Gene Name | malate dehydrogenase 2, NAD (mitochondrial) | ||||||||||||||||||||||
Synonyms | MDH; Mdh-2; Mor-1; Mor1 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000019179 | ||||||||||||||||||||||
Encoded Proteins |
malate dehydrogenase 2, NAD (mitochondrial)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146701:
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. [provided by RefSeq, Jul 2008] Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:135778480-135790398 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | G2 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Disease pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Glucose metabolism pathway
Metabolism pathway
Gluconeogenesis pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Glycogen storage diseases pathway
Citric acid cycle (TCA cycle) pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
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KEGG |
Citrate cycle (TCA cycle) pathway
Pyruvate metabolism pathway
Glyoxylate and dicarboxylate metabolism pathway
Cysteine and methionine metabolism pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Gluconeogenesis pathway
Citric acid cycle (TCA cycle) pathway
Myoclonic epilepsy of Lafora pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Metabolism of carbohydrates pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
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KEGG |
Pyruvate metabolism pathway
Citrate cycle (TCA cycle) pathway
Glyoxylate and dicarboxylate metabolism pathway
Cysteine and methionine metabolism pathway
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INOH |
Citrate cycle pathway
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PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P08249 | ||||||||||||||||||||||
TrEMBL | J3QMC8 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 17448 | ||||||||||||||||||||||
UniGene | Mm.399143 | ||||||||||||||||||||||
RefSeq | NM_008617 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19746 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:97050 | ||||||||||||||||||||||
MGI Symbol | Mdh2 | ||||||||||||||||||||||
EMBL | AC083948 AK002305 AK135162 AK160553 AK167809 BC023482 DQ402950 M16229 X07295 X07296 X07297 X07298 X07299 X07300 X07301 | ||||||||||||||||||||||
GenPept | AAA39509 AAH23482 ABD77283 BAC24986 BAE22447 BAE35869 BAE39836 CAA30274 | ||||||||||||||||||||||
RNA Seq Atlas | 17448 | ||||||||||||||||||||||