InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ywhag

Summary

InnateDB Gene

IDBG-204179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ywhag

Gene Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

Synonyms

14-3-3gamma; D7Bwg1348e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000051391

Encoded Proteins

IDBP-204181

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170027:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100%% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:135908409-135934616

Strand

Reverse strand

Band

Transcripts

ENSMUST00000055808	ENSMUSP00000051223
ENSMUST00000129581
ENSMUST00000126639
ENSMUST00000126192

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 279 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	42 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	279 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005080	protein kinase C binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0030971	receptor tyrosine kinase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006605	protein targeting
GO:0032869	cellular response to insulin stimulus
GO:0045664	regulation of neuron differentiation
GO:0048167	regulation of synaptic plasticity