Version 5.4
Mus musculus Gene: Mad2l2
Summary
InnateDB Gene IDBG-204215.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mad2l2
Gene Name MAD2 mitotic arrest deficient-like 2
Synonyms 2310033C13Rik; G1-453-4; MAD2B; repro22; REV7
Species Mus musculus
Ensembl Gene ENSMUSG00000029003
Encoded Proteins
IDBP-204217
MAD2 mitotic arrest deficient-like 2 (yeast)
IDBP-204219
MAD2 mitotic arrest deficient-like 2 (yeast)
IDBP-270309
MAD2 mitotic arrest deficient-like 2 (yeast)
IDBP-540210
MAD2 mitotic arrest deficient-like 2 (yeast)
IDBP-538422
MAD2 mitotic arrest deficient-like 2 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116670:
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:148130384-148145699
Strand Forward strand
Band E2
Transcripts
ENSMUST00000084129 ENSMUSP00000081146
ENSMUST00000030860 ENSMUSP00000030860
ENSMUST00000105708
ENSMUST00000105707 ENSMUSP00000101332
ENSMUST00000126261
ENSMUST00000132698 ENSMUSP00000122774
ENSMUST00000140049 ENSMUSP00000120481
ENSMUST00000148742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0005515 protein binding
GO:0008432 JUN kinase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001558 regulation of cell growth
GO:0006302 double-strand break repair
GO:0006351 transcription, DNA-templated
GO:0007015 actin filament organization
GO:0007067 mitotic nuclear division
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042177 negative regulation of protein catabolic process
GO:0042772 DNA damage response, signal transduction resulting in transcription
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060564 negative regulation of mitotic anaphase-promoting complex activity
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000678 negative regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005634 nucleus
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0016035 zeta DNA polymerase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116670
View Gene Order
ENSBTAG00000013275
Not yet available
Pathways
NETPATH
REACTOME
REACT_233397
DNA Repair pathway
REACT_215235
Translesion synthesis by Pol zeta pathway
REACT_218307
Translesion synthesis by DNA polymerases bypassing lesion on DNA template pathway
REACT_226050
DNA Damage Bypass pathway
KEGG
mmu04110
Cell cycle pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04114
Oocyte meiosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_822
Translesion synthesis by Pol zeta pathway
REACT_2198
Translesion synthesis by DNA polymerases bypassing lesion on DNA template pathway
REACT_2174
DNA Damage Bypass pathway
REACT_216
DNA Repair pathway
KEGG
hsa04110
Cell cycle pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.463446 Mm.9648
RefSeq NM_027985 XM_006535974 XM_006535976 XM_006535977 XM_006535978 XM_006539185 XM_006539186 XM_006539188 XM_006539189 XM_006539190
OMIM
CCDS CCDS18932
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca