Version 5.4
Mus musculus Gene: Fcer1g
Summary
InnateDB Gene IDBG-204231.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fcer1g
Gene Name Fc receptor, IgE, high affinity I, gamma polypeptide
Synonyms AI573376; CD23; Fce1g; FcepsilonRI; FcR-gamma; FcR[g]; FcRgamma; Ly-50
Species Mus musculus
Ensembl Gene ENSMUSG00000058715
Encoded Proteins
IDBP-204233
Fc receptor, IgE, high affinity I, gamma polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158869:
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171229572-171234365
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000079957 ENSMUSP00000078875
ENSMUST00000150997
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0019767 IgE receptor activity
GO:0019863 IgE binding
GO:0019864 IgG binding
Biological Process
GO:0001798 positive regulation of type IIa hypersensitivity
GO:0001805 positive regulation of type III hypersensitivity
GO:0001812 positive regulation of type I hypersensitivity
GO:0002283 neutrophil activation involved in immune response
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002554 serotonin secretion by platelet
GO:0006911 phagocytosis, engulfment
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0010543 regulation of platelet activation
GO:0016064 immunoglobulin mediated immune response
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030593 neutrophil chemotaxis
GO:0032733 positive regulation of interleukin-10 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032765 positive regulation of mast cell cytokine production
GO:0033026 negative regulation of mast cell apoptotic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042742 defense response to bacterium
GO:0043306 positive regulation of mast cell degranulation
GO:0045576 mast cell activation
GO:0050766 positive regulation of phagocytosis
GO:0050776 regulation of immune response
GO:0050778 positive regulation of immune response
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0032998 Fc-epsilon receptor I complex
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000158869
View Gene Order
ENSBTAG00000024503
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_224553
Hemostasis pathway
REACT_205561
FCERI mediated NF-kB activation pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_225107
Platelet Adhesion to exposed collagen pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_188202
FCERI mediated Ca+2 mobilization pathway
REACT_188530
FCERI mediated MAPK activation pathway
KEGG
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu05310
Asthma pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_15
IL3 pathway
NetPath_24
TSLP pathway
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_6900
Immune System pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
REACT_208597
Cell surface interactions at the vascular wall pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_216829
FCERI mediated Ca+2 mobilization pathway
REACT_219098
GPVI-mediated activation cascade pathway
REACT_219042
FCERI mediated NF-kB activation pathway
REACT_220688
Platelet Adhesion to exposed collagen pathway
REACT_224097
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_216714
Innate Immune System pathway
REACT_202074
FCERI mediated MAPK activation pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
KEGG
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05310
Asthma pathway
INOH
PID NCI
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt P20491
TrEMBL
UniProt Splice Variant
Entrez Gene 14127
UniGene
RefSeq NM_010185
OMIM
CCDS CCDS15483
HPRD
IMGT
MGI ID MGI:95496
MGI Symbol Fcer1g
EMBL BC034163 J05020
GenPept AAA37602 AAH34163
RNA Seq Atlas 14127

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca