InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdk5r1

Summary

InnateDB Gene

IDBG-204311.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk5r1

Gene Name

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Synonyms

Cdk5r; D11Bwg0379e; p25; p35

Species

Mus musculus

Ensembl Gene

ENSMUSG00000048895

Encoded Proteins

IDBP-204313

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

IDBP-531588

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176749:
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer\'s disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer\'s disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:80477023-80481184

Strand

Forward strand

Band

Transcripts

ENSMUST00000053413	ENSMUSP00000099514
ENSMUST00000147694	ENSMUSP00000120964

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0016301	kinase activity
GO:0016534	cyclin-dependent protein kinase 5 activator activity
GO:0019901	protein kinase binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0045296	cadherin binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007158	neuron cell-cell adhesion
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0007420	brain development
GO:0009790	embryo development
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0021549	cerebellum development
GO:0021722	superior olivary nucleus maturation
GO:0021766	hippocampus development
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021819	layer formation in cerebral cortex
GO:0030182	neuron differentiation
GO:0030517	negative regulation of axon extension
GO:0031175	neuron projection development
GO:0032956	regulation of actin cytoskeleton organization
GO:0033136	serine phosphorylation of STAT3 protein
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0043525	positive regulation of neuron apoptotic process
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048013	ephrin receptor signaling pathway
GO:0048511	rhythmic process
GO:0051726	regulation of cell cycle
GO:0061001	regulation of dendritic spine morphogenesis
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090314	positive regulation of protein targeting to membrane

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031594	neuromuscular junction
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043292	contractile fiber
GO:0048471	perinuclear region of cytoplasm