InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lrwd1

Summary

InnateDB Gene

IDBG-204387.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrwd1

Gene Name

leucine-rich repeats and WD repeat domain containing 1

Synonyms

1200011O22Rik; AU042569; AW548074; Orca

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029703

Encoded Proteins

IDBP-204389

leucine-rich repeats and WD repeat domain containing 1

IDBP-537940

leucine-rich repeats and WD repeat domain containing 1

IDBP-539036

leucine-rich repeats and WD repeat domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161036:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:136122772-136136074

Strand

Reverse strand

Band

Transcripts

ENSMUST00000006301	ENSMUSP00000006301
ENSMUST00000132976
ENSMUST00000142272
ENSMUST00000128255	ENSMUSP00000119546
ENSMUST00000148475
ENSMUST00000139908
ENSMUST00000149673
ENSMUST00000150406	ENSMUSP00000121513

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008327	methyl-CpG binding
GO:0035064	methylated histone binding

Biological Process

GO:0006260	DNA replication
GO:0006325	chromatin organization
GO:0016568	chromatin modification
GO:0071169	establishment of protein localization to chromatin

Cellular Component

GO:0005634	nucleus
GO:0005664	nuclear origin of replication recognition complex
GO:0005721	centromeric heterochromatin
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0031933	telomeric heterochromatin

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000161036

View Gene Order

ENSBTAG00000014742

Not yet available

Cross-References

SwissProt

Q8BUI3

TrEMBL

H9KV12

UniProt Splice Variant

Entrez Gene

71735

UniGene

Mm.425292 Mm.481109

RefSeq

NM_027891

OMIM

CCDS

CCDS51666

HPRD

IMGT

MGI ID

MGI:1918985

MGI Symbol

Lrwd1

EMBL

AC087420 AK004717 AK051910 AK084948 AK153976 AK167020 AK167868 BC048397

GenPept

AAH48397 BAB23500 BAC34810 BAC39318 BAE32292 BAE39194 BAE39884

RNA Seq Atlas

71735