Version 5.4
Mus musculus Gene: Dedd
Summary
InnateDB Gene IDBG-204417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dedd
Gene Name death effector domain-containing
Synonyms CASP8IP1; Dedpro1; DEFT; FLDED1; KE05
Species Mus musculus
Ensembl Gene ENSMUSG00000013973
Encoded Proteins
IDBP-204419
death effector domain-containing
IDBP-204421
death effector domain-containing
IDBP-258425
death effector domain-containing
IDBP-258427
death effector domain-containing
IDBP-542615
death effector domain-containing
IDBP-531985
death effector domain-containing
IDBP-536239
death effector domain-containing
IDBP-538342
death effector domain-containing
IDBP-532542
death effector domain-containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158796:
This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171329145-171342331
Strand Forward strand
Band H3
Transcripts
ENSMUST00000064950 ENSMUSP00000068419
ENSMUST00000097467 ENSMUSP00000095075
ENSMUST00000111300 ENSMUSP00000106931
ENSMUST00000111299 ENSMUSP00000106930
ENSMUST00000142063 ENSMUSP00000120861
ENSMUST00000129116 ENSMUSP00000120278
ENSMUST00000135150 ENSMUSP00000120993
ENSMUST00000157015 ENSMUSP00000119948
ENSMUST00000131653
ENSMUST00000127830 ENSMUSP00000122628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0042177 negative regulation of protein catabolic process
GO:0042981 regulation of apoptotic process
GO:0046697 decidualization
GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000158796
View Gene Order
ENSBTAG00000020154
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt Q9Z1L3
TrEMBL D3YZI2 D3Z0F7 D3Z0I1 D3Z4Q1 Q3U001
UniProt Splice Variant
Entrez Gene 21945
UniGene Mm.472271
RefSeq NM_001128609 NM_011615 XM_006496738 XM_006496739 XM_006496740 XM_006496741
OMIM
CCDS CCDS15490
HPRD
IMGT
MGI ID MGI:1333874
MGI Symbol Dedd
EMBL AC084821 AF100342 AJ011386 AK157342 BC023668 BC054445 CH466520
GenPept AAD16415 AAH23668 AAH54445 BAE34055 CAA09604 EDL39096 EDL39097 EDL39098 EDL39099 EDL39100 EDL39101
RNA Seq Atlas 21945

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca