Mus musculus Gene: F11r | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-204606.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | F11r | ||||||||||||||||||||||
Gene Name | F11 receptor | ||||||||||||||||||||||
Synonyms | 9130004G24; AA638916; ESTM33; JAM; JAM-1; JAM-A; Jcam; Jcam1; Ly106 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000038235 | ||||||||||||||||||||||
Encoded Proteins |
F11 receptor
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158769:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 1:171437535-171464603 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | H3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Disease pathway
Hemostasis pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell-cell junction organization pathway
Cell surface interactions at the vascular wall pathway
Extracellular matrix organization pathway
Loss of Function of TGFBR2 in Cancer pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Integrin cell surface interactions pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Cell junction organization pathway
Tight junction interactions pathway
Cell-Cell communication pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
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KEGG |
Tight junction pathway
Cell adhesion molecules (CAMs) pathway
Leukocyte transendothelial migration pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cell surface interactions at the vascular wall pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Integrin cell surface interactions pathway
Tight junction interactions pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Cell-Cell communication pathway
Extracellular matrix organization pathway
Cell junction organization pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell-cell junction organization pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Disease pathway
Hemostasis pathway
Signaling by TGF-beta Receptor Complex pathway
Cell surface interactions at the vascular wall pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Extracellular matrix organization pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Hemostasis pathway
Cell junction organization pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
Cell-Cell communication pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Integrin cell surface interactions pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Cell-cell junction organization pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Disease pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Tight junction interactions pathway
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KEGG |
Cell adhesion molecules (CAMs) pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Integrins in angiogenesis
Beta2 integrin cell surface interactions
Nectin adhesion pathway
Beta3 integrin cell surface interactions
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Cross-References | |||||||||||||||||||||||
SwissProt | O88792 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 16456 | ||||||||||||||||||||||
UniGene | Mm.294882 Mm.410513 | ||||||||||||||||||||||
RefSeq | NM_172647 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS15496 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1321398 | ||||||||||||||||||||||
MGI Symbol | F11r | ||||||||||||||||||||||
EMBL | AC087229 AK033574 BC021876 CT010347 U89915 | ||||||||||||||||||||||
GenPept | AAC32982 AAH21876 BAC28369 CAJ18555 | ||||||||||||||||||||||
RNA Seq Atlas | 16456 | ||||||||||||||||||||||