InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Serpine1

Summary

InnateDB Gene

IDBG-204786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpine1

Gene Name

serine (or cysteine) peptidase inhibitor, clade E, member 1

Synonyms

PAI-1; PAI1; Planh1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037411

Encoded Proteins

IDBP-204788

serine (or cysteine) peptidase inhibitor, clade E, member 1

IDBP-204790

serine (or cysteine) peptidase inhibitor, clade E, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21768189

Serpine1 is a critical mediator that controls the development of the early lung inflammation induced by Pseudomonas aeruginosa infections.

PMID 21945446

Serpine1 plays a critical role in early host defense response against Haemophilus influenzae infection. Serpine1 knockout mice show reduced bacterial clearance and prolonged pneumonia.

InnateDB Annotation from Orthologs

Summary

PMID 21768189

[Homo sapiens] SERPINE1 is a critical mediator of the pulmonary host response that controls the development of the early lung inflammation induced by Pseudomonas aeruginosa infections. (Demonstrated in mouse)

PMID 21945446

[Homo sapiens] SERPINE1 plays a critical role in early host defense response against Haemophilus influenzae infection. Serpine1 knockout mice show reduced bacterial clearance and prolonged pneumonia. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106366:
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:137061504-137072272

Strand

Reverse strand

Band

Transcripts

ENSMUST00000041388	ENSMUSP00000039586
ENSMUST00000077523	ENSMUSP00000076728

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0001300	chronological cell aging
GO:0001525	angiogenesis
GO:0010469	regulation of receptor activity
GO:0010757	negative regulation of plasminogen activation
GO:0010951	negative regulation of endopeptidase activity
GO:0014912	negative regulation of smooth muscle cell migration
GO:0030194	positive regulation of blood coagulation
GO:0030336	negative regulation of cell migration
GO:0032757	positive regulation of interleukin-8 production
GO:0033629	negative regulation of cell adhesion mediated by integrin
GO:0035491	positive regulation of leukotriene production involved in inflammatory response
GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045765	regulation of angiogenesis
GO:0045766	positive regulation of angiogenesis
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0050729	positive regulation of inflammatory response
GO:0050829	defense response to Gram-negative bacterium
GO:0051918	negative regulation of fibrinolysis
GO:0061044	negative regulation of vascular wound healing
GO:0071222	cellular response to lipopolysaccharide
GO:0090026	positive regulation of monocyte chemotaxis
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000098	negative regulation of smooth muscle cell-matrix adhesion
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000106366

View Gene Order

ENSBTAG00000014465

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04115

p53 signaling pathway pathway

mmu04610

Complement and coagulation cascades pathway

mmu05142

Chagas disease (American trypanosomiasis) pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_56

Prolactin pathway

REACTOME

REACT_641

Dissolution of Fibrin Clot pathway

REACT_318

Platelet degranulation pathway

REACT_1280

Response to elevated platelet cytosolic Ca2+ pathway

REACT_120734

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway

REACT_111118

BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway

REACT_24941

Circadian Clock pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_169107

SMAD4 MH2 Domain Mutants in Cancer pathway

REACT_169219

Loss of Function of SMAD4 in Cancer pathway

REACT_169398

Loss of Function of SMAD2/3 in Cancer pathway

REACT_118779

Extracellular matrix organization pathway

REACT_169122

Signaling by TGF-beta Receptor Complex in Cancer pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_169192

TGFBR2 MSI Frameshift Mutants in Cancer pathway

REACT_111102

Signal Transduction pathway

REACT_121061

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway

REACT_169165

SMAD2/3 MH2 Domain Mutants in Cancer pathway

REACT_169435

Loss of Function of TGFBR2 in Cancer pathway

REACT_169103

SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway

REACT_163906

ECM proteoglycans pathway

REACT_169263

TGFBR1 KD Mutants in Cancer pathway

REACT_169311

Loss of Function of TGFBR1 in Cancer pathway

REACT_169445

TGFBR1 LBD Mutants in Cancer pathway

REACT_169440

TGFBR2 Kinase Domain Mutants in Cancer pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

REACT_604

Hemostasis pathway

REACT_6844

Signaling by TGF-beta Receptor Complex pathway

REACT_202252

Platelet degranulation pathway

REACT_223425

Extracellular matrix organization pathway

REACT_212196

Hemostasis pathway

REACT_209572

Platelet activation, signaling and aggregation pathway

REACT_212308

Response to elevated platelet cytosolic Ca2+ pathway

REACT_222217

ECM proteoglycans pathway

REACT_210271

BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway

REACT_207584

Dissolution of Fibrin Clot pathway

REACT_227144

Circadian Clock pathway

KEGG

hsa04610

Complement and coagulation cascades pathway

hsa04115

p53 signaling pathway pathway

hsa05142

Chagas disease (American trypanosomiasis) pathway

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

upa_upar_pathway

Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

hif2pathway

HIF-2-alpha transcription factor network

p73pathway

p73 transcription factor network

e2f_pathway

E2F transcription factor network

smad2_3nuclearpathway

Regulation of nuclear SMAD2/3 signaling

hif1_tfpathway

HIF-1-alpha transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.250422

RefSeq

NM_008871

OMIM

CCDS

CCDS19761

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas