InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cd48

Summary

InnateDB Gene

IDBG-204791.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd48

Gene Name

CD48 antigen

Synonyms

AI449234; AW610730; Bcm-1; BCM1; BLAST; BLAST-1; BLAST1; MEM-102; Sgp-60; SLAMF2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015355

Encoded Proteins

IDBP-204793

CD48 antigen

IDBP-204795

CD48 antigen

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26564814

Invariant natural killer T cell activation induced by mast cells exposed to alpha-galactosylceramide is regulated by costimulatory molecules Cd48 and Tnfsf4.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117091:
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:171682009-171705258

Strand

Forward strand

Band

Transcripts

ENSMUST00000015499	ENSMUSP00000015499
ENSMUST00000068584	ENSMUSP00000064241

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0042110	T cell activation
GO:0045087	innate immune response (InnateDB)
GO:0045576	mast cell activation

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0046658	anchored component of plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000117091

View Gene Order

ENSBTAG00000011238

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_225233

Cell surface interactions at the vascular wall pathway

KEGG

mmu04650

Natural killer cell mediated cytotoxicity pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_604

Hemostasis pathway

KEGG

hsa04650

Natural killer cell mediated cytotoxicity pathway

INOH

PID NCI

Cross-References

SwissProt

P18181

TrEMBL

F8WHM0 Q9R1N8

UniProt Splice Variant

Entrez Gene

12506

UniGene

Mm.1738 Mm.470936

RefSeq

NM_007649

OMIM

CCDS

CCDS15501

HPRD

IMGT

MGI ID

MGI:88339

MGI Symbol

Cd48

EMBL

AC091521 AF064620 AK007741 AK084984 AK151601 X17501 X53526

GenPept

AAD42985 BAB25228 BAC39328 BAE30541 CAA35542 CAA37604

RNA Seq Atlas

12506