Version 5.4
Mus musculus Gene: Trim56
Summary
InnateDB Gene IDBG-204815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trim56
Gene Name tripartite motif-containing 56
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000043279
Encoded Proteins
IDBP-204817
tripartite motif-containing 56
IDBP-539349
tripartite motif-containing 56
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21289118
Trim56 is an anti-viral host factor that restricts pestivirus infection, specifically it was found to impair bovine viral diarrhoea virus replication.
PMID 22948160
TRIM56 is an essential component of the TLR3 anti-viral signalling pathway. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 21074459
[Homo sapiens] TRIM56 is a regulator of double-stranded DNA-mediated type I interferon induction where it acts as an interferon-inducible E3 ubiquitin ligase that modulates STING to confer double-stranded DNA-mediated innate immune responses.
PMID 21289118
[Homo sapiens] TRIM56 is an anti-viral host factor that restricts pestivirus infection, specifically it was found to impair bovine viral diarrhoea virus replication.
PMID 22948160
[Homo sapiens] TRIM56 is an essential component of the TLR3 anti-viral signalling pathway.
PMID 23438823
[Homo sapiens] TRIM56 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169871:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:137105644-137116209
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000054384 ENSMUSP00000058109
ENSMUST00000152207 ENSMUSP00000117874
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0032608 interferon-beta production
GO:0034340 response to type I interferon
GO:0045087 innate immune response (InnateDB)
GO:0046597 negative regulation of viral entry into host cell
GO:0051607 defense response to virus
GO:0070534 protein K63-linked ubiquitination
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169871
View Gene Order
ENSBTAG00000012038
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_230745
Immune System pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_196519
Regulation of innate immune responses to cytosolic DNA pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6802
Innate Immune System pathway
REACT_163977
Regulation of innate immune responses to cytosolic DNA pathway
REACT_6900
Immune System pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q80VI1
TrEMBL D3YVX5
UniProt Splice Variant
Entrez Gene 384309
UniGene Mm.100647 Mm.194530 Mm.22973 Mm.408227
RefSeq NM_201373 XM_006504441 XM_006504442
OMIM
CCDS CCDS19762
HPRD
IMGT
MGI ID MGI:2685298
MGI Symbol Trim56
EMBL AC147986 AK037350 BC045615
GenPept AAH45615 BAC29792
RNA Seq Atlas 384309

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca