InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dffa

Summary

InnateDB Gene

IDBG-204894.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dffa

Gene Name

DNA fragmentation factor, alpha subunit

Synonyms

A330085O09Rik; DFF35; Dff45; ICAD; ICAD-L; ICAD-S

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028974

Encoded Proteins

IDBP-204896

DNA fragmentation factor, alpha subunit

IDBP-204898

DNA fragmentation factor, alpha subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160049:
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:149104146-149120647

Strand

Forward strand

Band

Transcripts

ENSMUST00000103216	ENSMUSP00000099505
ENSMUST00000030816	ENSMUSP00000030816
ENSMUST00000153781

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006309	apoptotic DNA fragmentation
GO:0006915	apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0070242	thymocyte apoptotic process
GO:1900118	negative regulation of execution phase of apoptosis
GO:1902511	negative regulation of apoptotic DNA fragmentation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000160049

View Gene Order

ENSBTAG00000013535

Not yet available

Pathways

NETPATH

REACTOME

REACT_258521

Apoptosis pathway

REACT_215449

Apoptosis induced DNA fragmentation pathway

REACT_205002

Activation of DNA fragmentation factor pathway

REACT_207035

Apoptotic execution phase pathway

KEGG

mmu04210

Apoptosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_13462

Activation of DNA fragmentation factor pathway

REACT_995

Apoptotic execution phase pathway

REACT_1213

Apoptosis induced DNA fragmentation pathway

REACT_578

Apoptosis pathway

KEGG

hsa04210

Apoptosis pathway

INOH

PID NCI

caspase_pathway

Caspase Cascade in Apoptosis

Cross-References

SwissProt

O54786

TrEMBL

UniProt Splice Variant

Entrez Gene

13347

UniGene

Mm.41433

RefSeq

NM_001025296 NM_010044

OMIM

CCDS

CCDS18951 CCDS18952

HPRD

IMGT

MGI ID

MGI:1196227

MGI Symbol

Dffa

EMBL

AB009375 AB009376 AK051011 AL611967 CU210839

GenPept

BAA24140 BAA24141 BAC34496 CAM13988 CAQ52098

RNA Seq Atlas

13347