InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FST

Summary

InnateDB Gene

IDBG-20490.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FST

Gene Name

follistatin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000134363

Encoded Proteins

IDBP-20492

follistatin

IDBP-236436

follistatin

IDBP-478243

follistatin

IDBP-476996

follistatin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:53480409-53487134

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000256759	ENSP00000256759
ENST00000396947	ENSP00000380151
ENST00000491717
ENST00000504226	ENSP00000426315
ENST00000497789	ENSP00000426971

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	16 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0048185	activin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0007276	gamete generation
GO:0007389	pattern specification process
GO:0008585	female gonad development
GO:0030509	BMP signaling pathway
GO:0031069	hair follicle morphogenesis
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043616	keratinocyte proliferation
GO:0045596	negative regulation of cell differentiation
GO:0051798	positive regulation of hair follicle development

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021765

View Gene Order

ENSBTAG00000003329

Not yet available

Pathways

NETPATH

REACTOME

REACT_150276

Antagonism of Activin by Follistatin pathway

REACT_150238

Signaling by Activin pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04350

TGF-beta signaling pathway pathway

INOH

PID NCI

bmppathway

BMP receptor signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.683607 Hs.743863 Hs.9914

RefSeq

NM_006350 NM_013409 XM_005248401 XM_005248403

HUGO

OMIM

CCDS

CCDS3959 CCDS43315

HPRD

00641

IMGT

EMBL

GenPept

RNA Seq Atlas