Mus musculus Gene: Ephb4 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-204963.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Ephb4 | ||||||||||||||||||||||
Gene Name | Eph receptor B4 | ||||||||||||||||||||||
Synonyms | AI042935; Htk; MDK2; Myk1; Tyro11 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000029710 | ||||||||||||||||||||||
Encoded Proteins |
Eph receptor B4
Eph receptor B4
Eph receptor B4
Eph receptor B4
Eph receptor B4
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196411:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:137350109-137378669 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | G2 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Developmental Biology pathway
Ephrin signaling pathway
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KEGG |
Axon guidance pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
EGFR1 pathway
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REACTOME |
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Ephrin signaling pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
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KEGG |
Axon guidance pathway
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INOH | |||||||||||||||||||||||
PID NCI |
EPHB forward signaling
Ephrin B reverse signaling
EphrinB-EPHB pathway
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Cross-References | |||||||||||||||||||||||
SwissProt | P54761 | ||||||||||||||||||||||
TrEMBL | E9PWK7 Q8C8K1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 13846 | ||||||||||||||||||||||
UniGene | Mm.34533 Mm.487766 | ||||||||||||||||||||||
RefSeq | NM_001159571 NM_010144 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19767 CCDS51671 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:104757 | ||||||||||||||||||||||
MGI Symbol | Ephb4 | ||||||||||||||||||||||
EMBL | AC150682 AF312033 AK046884 CH466529 U06834 Z49085 | ||||||||||||||||||||||
GenPept | AAA18591 AAK28823 BAC32908 CAA88909 EDL19273 EDL19275 | ||||||||||||||||||||||
RNA Seq Atlas | 13846 | ||||||||||||||||||||||