InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Taf10

Summary

InnateDB Gene

IDBG-204983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf10

Gene Name

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Synonyms

30kDa; AU041226; Taf2h; TAFII30

Species

Mus musculus

Ensembl Gene

ENSMUSG00000043866

Encoded Proteins

IDBP-537697

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166337:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:105739393-105744361

Strand

Reverse strand

Band

Transcripts

ENSMUST00000054556
ENSMUST00000141116	ENSMUSP00000118105
ENSMUST00000131683
ENSMUST00000146999

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001889	liver development
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0010468	regulation of gene expression
GO:0035264	multicellular organism growth
GO:0043623	cellular protein complex assembly
GO:0051101	regulation of DNA binding
GO:0070365	hepatocyte differentiation