InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pex19

Summary

InnateDB Gene

IDBG-205149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pex19

Gene Name

peroxisomal biogenesis factor 19

Synonyms

Pxf

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003464

Encoded Proteins

IDBP-205151

peroxisomal biogenesis factor 19

IDBP-258537

peroxisomal biogenesis factor 19

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162735:
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:172126755-172136493

Strand

Forward strand

Band

Transcripts

ENSMUST00000075895	ENSMUSP00000075289
ENSMUST00000111252	ENSMUSP00000106883
ENSMUST00000147799
ENSMUST00000133546
ENSMUST00000127662
ENSMUST00000133081

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0036105	peroxisome membrane class-1 targeting sequence binding
GO:0047485	protein N-terminus binding
GO:0051117	ATPase binding

Biological Process

GO:0006625	protein targeting to peroxisome
GO:0007031	peroxisome organization
GO:0016557	peroxisome membrane biogenesis
GO:0016559	peroxisome fission
GO:0045046	protein import into peroxisome membrane
GO:0050821	protein stabilization
GO:0061077	chaperone-mediated protein folding
GO:0072321	chaperone-mediated protein transport
GO:0072663	establishment of protein localization to peroxisome
GO:1900131	negative regulation of lipid binding

Cellular Component

GO:0005634	nucleus
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex