Version 5.4
Mus musculus Gene: Cops6
Summary
InnateDB Gene IDBG-205825.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cops6
Gene Name COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)
Synonyms Sgn3; VIP/MOV34
Species Mus musculus
Ensembl Gene ENSMUSG00000019494
Encoded Proteins
IDBP-205827
COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)
IDBP-259162
COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)
IDBP-532170
COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168090:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:138161071-138164646
Strand Forward strand
Band G2
Transcripts
ENSMUST00000019638 ENSMUSP00000019638
ENSMUST00000110951 ENSMUSP00000106576
ENSMUST00000127881
ENSMUST00000154867
ENSMUST00000132639 ENSMUSP00000121554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 272 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 272 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168090
View Gene Order
ENSBTAG00000002871
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3981
RefSeq NM_012002
OMIM
CCDS CCDS19792
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca