InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2L3

Summary

InnateDB Gene

IDBG-2059.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2L3

Gene Name

ubiquitin-conjugating enzyme E2L 3

Synonyms

E2-F1; L-UBC; UBCH7; UbcM4

Species

Homo sapiens

Ensembl Gene

ENSG00000185651

Encoded Proteins

IDBP-2061

ubiquitin-conjugating enzyme E2L 3

IDBP-365099

ubiquitin-conjugating enzyme E2L 3

IDBP-594947

ubiquitin-conjugating enzyme E2L 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:21549447-21624034

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000342192	ENSP00000344259
ENST00000458578	ENSP00000400906
ENST00000496722
ENST00000545681	ENSP00000445931

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	128 [view]
Protein-Protein	128 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006464	cellular protein modification process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008283	cell proliferation
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0071383	cellular response to steroid hormone stimulus
GO:0071385	cellular response to glucocorticoid stimulus

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038965

View Gene Order

ENSBTAG00000013038

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

hsa05012

Parkinson's disease pathway

INOH

PID NCI

alphasynuclein_pathway

Alpha-synuclein signaling

bard1pathway

BARD1 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.108104 Hs.446584 Hs.613248

RefSeq

NM_001256355 NM_001256356 NM_003347

HUGO

OMIM

CCDS

CCDS13790 CCDS58795 CCDS58796

HPRD

04762

IMGT

EMBL

GenPept

RNA Seq Atlas