InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Taf6

Summary

InnateDB Gene

IDBG-205942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf6

Gene Name

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Synonyms

80kDa; AW549759; p80; TAF(II)80; Taf2e; TAFII70

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036980

Encoded Proteins

IDBP-205944

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-259186

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-259188

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-790485

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-534132

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-531786

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106290:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:138178617-138187451

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048698	ENSMUSP00000048016
ENSMUST00000110937	ENSMUSP00000106562
ENSMUST00000110936	ENSMUSP00000106561
ENSMUST00000153117	ENSMUSP00000138335
ENSMUST00000130473
ENSMUST00000123415	ENSMUSP00000122534
ENSMUST00000139276	ENSMUSP00000116512

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0045786	negative regulation of cell cycle
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity