Version 5.4
Mus musculus Gene: Per3
Summary
InnateDB Gene IDBG-205972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Per3
Gene Name period homolog 3 (Drosophila)
Synonyms 2810049O06Rik; mPer3
Species Mus musculus
Ensembl Gene ENSMUSG00000028957
Encoded Proteins
IDBP-205974
period homolog 3 (Drosophila)
IDBP-532447
period homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:151003652-151044665
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000103204 ENSMUSP00000099493
ENSMUST00000138052
ENSMUST00000138584
ENSMUST00000136398 ENSMUSP00000118950
ENSMUST00000128283
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0032922 circadian regulation of gene expression
GO:0045187 regulation of circadian sleep/wake cycle, sleep
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000049246
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04710
Circadian rhythm pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04710
Circadian rhythm pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.121361 Mm.470724
RefSeq NM_001289877 NM_011067 XM_006537066 XM_006537067 XM_006538634 XM_006538635 XM_006538636 XM_006538640
OMIM
CCDS CCDS18978
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca