InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Brip1

Summary

InnateDB Gene

IDBG-206741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brip1

Gene Name

BRCA1 interacting protein C-terminal helicase 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034329

Encoded Proteins

IDBP-206743

BRCA1 interacting protein C-terminal helicase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the DEAH subfamily of DEAD box helicases. A similar protein in humans is both a DNA-dependent ATPase and a 5-prime-to-3-prime DNA helicase, and plays a role in the repair of DNA double stranded breaks through interaction with the breast cancer-associated tumor suppressor BRCA1. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:86058138-86201193

Strand

Reverse strand

Band

Transcripts

ENSMUST00000044423	ENSMUSP00000043108
ENSMUST00000149748
ENSMUST00000123366

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0032508	DNA duplex unwinding