InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hnrnpu

Summary

InnateDB Gene

IDBG-206838.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpu

Gene Name

heterogeneous nuclear ribonucleoprotein U

Synonyms

AA408410; AI256620; AL024194; AL024437; AW557595; C86794; hnRNP U; Hnrpu; SAFA; Sp120

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039630

Encoded Proteins

IDBP-206840

heterogeneous nuclear ribonucleoprotein U

IDBP-537712

heterogeneous nuclear ribonucleoprotein U

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153187:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:178324343-178337797

Strand

Reverse strand

Band

Transcripts

ENSMUST00000037748	ENSMUSP00000047571
ENSMUST00000161769	ENSMUSP00000124147
ENSMUST00000162916
ENSMUST00000150825
ENSMUST00000146362
ENSMUST00000134291

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 216 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	216 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0009986	cell surface
GO:0070937	CRD-mediated mRNA stability complex
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000153187

View Gene Order

ENSBTAG00000007606

Not yet available

Pathways

NETPATH

REACTOME

REACT_249110

mRNA Splicing pathway

REACT_233572

Gene Expression pathway

REACT_260226

mRNA Splicing - Major Pathway pathway

REACT_233950

Processing of Capped Intron-Containing Pre-mRNA pathway

KEGG

mmu03040

Spliceosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.467653 Mm.86589

RefSeq

NM_016805

OMIM

CCDS

CCDS35804

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas