Version 5.4
Mus musculus Gene: Rps6kb1
Summary
InnateDB Gene IDBG-206895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rps6kb1
Gene Name ribosomal protein S6 kinase, polypeptide 1
Synonyms 2610318I15Rik; 4732464A07Rik; 70kDa; AA959758; AI256796; AI314060; p70/85s6k; p70s6k; S6K1
Species Mus musculus
Ensembl Gene ENSMUSG00000020516
Encoded Proteins
IDBP-206899
ribosomal protein S6 kinase, polypeptide 1
IDBP-541289
ribosomal protein S6 kinase, polypeptide 1
IDBP-539893
ribosomal protein S6 kinase, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108443:
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:86498871-86544805
Strand Reverse strand
Band C
Transcripts
ENSMUST00000020824
ENSMUST00000058286 ENSMUSP00000053188
ENSMUST00000154617 ENSMUSP00000119715
ENSMUST00000149392
ENSMUST00000131194
ENSMUST00000151748
ENSMUST00000138810 ENSMUSP00000122756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042277 peptide binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0003009 skeletal muscle contraction
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007281 germ cell development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007616 long-term memory
GO:0009408 response to heat
GO:0009611 response to wounding
GO:0009612 response to mechanical stimulus
GO:0009636 response to toxic substance
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0014732 skeletal muscle atrophy
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016477 cell migration
GO:0031929 TOR signaling
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0032870 cellular response to hormone stimulus
GO:0033574 response to testosterone
GO:0033762 response to glucagon
GO:0034612 response to tumor necrosis factor
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043200 response to amino acid
GO:0043201 response to leucine
GO:0043434 response to peptide hormone
GO:0043491 protein kinase B signaling
GO:0045471 response to ethanol
GO:0045727 positive regulation of translation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045948 positive regulation of translational initiation
GO:0046324 regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051384 response to glucocorticoid
GO:0071363 cellular response to growth factor stimulus
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0009986 cell surface
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108443
View Gene Order
ENSBTAG00000016851
Not yet available
Pathways
NETPATH
REACTOME
REACT_240250
Signaling by Insulin receptor pathway
REACT_229737
S6K1 signalling pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_260675
S6K1-mediated signalling pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_240139
PI3K Cascade pathway
REACT_243154
IRS-related events pathway
REACT_242206
IRS-mediated signalling pathway
REACT_231630
mTORC1-mediated signalling pathway
REACT_188257
Signal Transduction pathway
REACT_255725
mTOR signalling pathway
REACT_256714
PKB-mediated events pathway
KEGG
mmu04012
ErbB signaling pathway pathway
mmu04350
TGF-beta signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu05221
Acute myeloid leukemia pathway
mmu04150
mTOR signaling pathway pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_16
IL4 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_56
Prolactin pathway
NetPath_147
IL11 pathway
REACTOME
REACT_6772
S6K1 signalling pathway
REACT_6754
S6K1-mediated signalling pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_456
PKB-mediated events pathway
REACT_6964
mTORC1-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_206974
Insulin receptor signalling cascade pathway
REACT_226714
S6K1-mediated signalling pathway
REACT_213280
PKB-mediated events pathway
REACT_225366
IRS-related events triggered by IGF1R pathway
REACT_216992
mTOR signalling pathway
REACT_208701
mTORC1-mediated signalling pathway
REACT_208835
IRS-related events pathway
REACT_224404
IRS-mediated signalling pathway
REACT_205176
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_216354
IGF1R signaling cascade pathway
REACT_214353
Signal Transduction pathway
REACT_222737
S6K1 signalling pathway
REACT_209911
PI3K Cascade pathway
REACT_219546
Signaling by Insulin receptor pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04012
ErbB signaling pathway pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
PID NCI
rxr_vdr_pathway
RXR and RAR heterodimerization with other nuclear receptor
avb3_integrin_pathway
Integrins in angiogenesis
mtor_4pathway
mTOR signaling pathway
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
igf1_pathway
IGF1 pathway
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
il4_2pathway
IL4-mediated signaling events
cdc42_pathway
CDC42 signaling events
tgfbrpathway
TGF-beta receptor signaling
il2_pi3kpathway
IL2 signaling events mediated by PI3K
insulin_pathway
Insulin Pathway
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.394280 Mm.470750 Mm.486655
RefSeq NM_001114334 NM_028259 XM_006534314 XM_006534315 XM_006534316 XM_006534317 XM_006534318
OMIM
CCDS CCDS25201 CCDS48875
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca