Version 5.4
Mus musculus Gene: Trp73
Summary
InnateDB Gene IDBG-206900.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trp73
Gene Name transformation related protein 73
Synonyms p73; TAp73; Tp73
Species Mus musculus
Ensembl Gene ENSMUSG00000029026
Encoded Proteins
IDBP-625214
transformation related protein 73
IDBP-206906
transformation related protein 73
IDBP-270438
transformation related protein 73
IDBP-270440
transformation related protein 73
IDBP-542102
transformation related protein 73
IDBP-717591
IDBP-536457
transformation related protein 73
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22976836
Trp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses.
InnateDB Annotation from Orthologs
Summary
PMID 22976836
[Homo sapiens] TP73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses. (Demonstrated in mouse)
Entrez Gene
Summary This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]
This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other\'s promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:154056253-154140208
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000097763 ENSMUSP00000134196
ENSMUST00000097762 ENSMUSP00000095368
ENSMUST00000105644 ENSMUSP00000101269
ENSMUST00000105643 ENSMUSP00000101268
ENSMUST00000133533 ENSMUSP00000114418
ENSMUST00000155642 ENSMUSP00000135281
ENSMUST00000139634 ENSMUSP00000114736
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 102 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 102 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000187 activation of MAPK activity
GO:0001822 kidney development
GO:0001836 release of cytochrome c from mitochondria
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050 cell cycle arrest
GO:0009791 post-embryonic development
GO:0010165 response to X-ray
GO:0010243 response to organonitrogen compound
GO:0010332 response to gamma radiation
GO:0021766 hippocampus development
GO:0030900 forebrain development
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0033326 cerebrospinal fluid secretion
GO:0034644 cellular response to UV
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065 positive regulation of apoptotic process
GO:0043508 negative regulation of JUN kinase activity
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045665 negative regulation of neuron differentiation
GO:0045793 positive regulation of cell size
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048546 digestive tract morphogenesis
GO:0048666 neuron development
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051262 protein tetramerization
GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078900
View Gene Order
ENSBTAG00000005812
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04115
p53 signaling pathway pathway
mmu04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
p73pathway
p73 transcription factor network
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.78015
RefSeq NM_001126330 NM_001126331 NM_011642 XM_006538720 XM_006538721 XM_006538722 XM_006538723
OMIM
CCDS CCDS19009 CCDS51396 CCDS51397
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca