Version 5.4
Homo sapiens Gene: DCTN5
Summary
InnateDB Gene IDBG-20705.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCTN5
Gene Name dynactin 5 (p25)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166847
Encoded Proteins
IDBP-20707
dynactin 5 (p25)
IDBP-752058
IDBP-752521
IDBP-750666
IDBP-749856
IDBP-745976
IDBP-750248
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:23641392-23677455
Strand Forward strand
Band p12.2
Transcripts
ENST00000300087 ENSP00000300087
ENST00000563188 ENSP00000456483
ENST00000566298 ENSP00000458354
ENST00000563998 ENSP00000454691
ENST00000568589 ENSP00000456137
ENST00000566053 ENSP00000457585
ENST00000568272 ENSP00000455685
ENST00000563614
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005813 centrosome
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030868
View Gene Order
ENSBTAG00000006410
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt Q9BTE1
TrEMBL I3L0U8
UniProt Splice Variant
Entrez Gene 84516
UniGene Hs.435941 Hs.607464
RefSeq NM_001199743 NM_001199011 NM_032486
HUGO HGNC:24594
OMIM 612962
CCDS CCDS58436 CCDS10615 CCDS58435
HPRD 14551
IMGT
EMBL AC008870 AK027387 AK292843 BC004191 CD388246 CH471145
GenPept AAH04191 BAB55077 BAF85532 EAW55809 EAW55810
RNA Seq Atlas 84516

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca