Version 5.4
Mus musculus Gene: Itpkb
Summary
InnateDB Gene IDBG-207161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itpkb
Gene Name inositol 1,4,5-trisphosphate 3-kinase B
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038855
Encoded Proteins
IDBP-207163
inositol 1,4,5-trisphosphate 3-kinase B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143772:
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:180330485-180424802
Strand Forward strand
Band H4
Transcripts
ENSMUST00000070181 ENSMUSP00000069851
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
Biological Process
GO:0000165 MAPK cascade
GO:0007166 cell surface receptor signaling pathway
GO:0030217 T cell differentiation
GO:0045059 positive thymic T cell selection
GO:0045061 thymic T cell selection
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046638 positive regulation of alpha-beta T cell differentiation
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143772
View Gene Order
ENSBTAG00000019339
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04020
Calcium signaling pathway pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL B2RXC2 Q8BKB2
UniProt Splice Variant
Entrez Gene 320404
UniGene Mm.132535
RefSeq NM_001081175 XM_006496903
OMIM
CCDS CCDS35808
HPRD
IMGT
MGI ID MGI:109235
MGI Symbol Itpkb
EMBL AC121838 AK053759 BC151160 BC157986 BC158000 CH466555
GenPept AAI51161 AAI57987 AAI58001 BAC35509 EDL13155
RNA Seq Atlas 320404

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca