Version 5.4
Mus musculus Gene: Plch2
Summary
InnateDB Gene IDBG-207301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plch2
Gene Name phospholipase C, eta 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000029055
Encoded Proteins
IDBP-270464
phospholipase C, eta 2
IDBP-533436
phospholipase C, eta 2
IDBP-536599
phospholipase C, eta 2
IDBP-538492
phospholipase C, eta 2
IDBP-534086
phospholipase C, eta 2
IDBP-539224
phospholipase C, eta 2
IDBP-535294
phospholipase C, eta 2
IDBP-718601
IDBP-718966
IDBP-790092
phospholipase C, eta 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149527:
PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:154983115-155056784
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000105631 ENSMUSP00000101256
ENSMUST00000127661
ENSMUST00000139976 ENSMUSP00000122704
ENSMUST00000124517 ENSMUSP00000122139
ENSMUST00000135665 ENSMUSP00000118292
ENSMUST00000145662 ENSMUSP00000119864
ENSMUST00000131173 ENSMUSP00000118629
ENSMUST00000126098 ENSMUSP00000115440
ENSMUST00000176194 ENSMUSP00000134750
ENSMUST00000175982 ENSMUSP00000135209
ENSMUST00000176620
ENSMUST00000186598 ENSMUSP00000141152
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0046488 phosphatidylinositol metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149527
View Gene Order
ENSBTAG00000002464
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_196476
Inositol phosphate metabolism pathway
REACT_196473
Synthesis of IP3 and IP4 in the cytosol pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q6PAS6
UniProt Splice Variant
Entrez Gene 269615
UniGene
RefSeq NM_001113360 NM_175556 XM_006538940 XM_006538942
OMIM
CCDS CCDS38990 CCDS71533
HPRD
IMGT
MGI ID MGI:2443078
MGI Symbol Plch2
EMBL BC060083
GenPept AAH60083
RNA Seq Atlas 269615

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca