Version 5.4
Mus musculus Gene: Trp53bp2
Summary
InnateDB Gene IDBG-207716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trp53bp2
Gene Name transformation related protein 53 binding protein 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026510
Encoded Proteins
IDBP-400246
transformation related protein 53 binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143514:
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:182409172-182462432
Strand Forward strand
Band H5
Transcripts
ENSMUST00000117245 ENSMUSP00000112508
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0042802 identical protein binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0007049 cell cycle
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0009792 embryo development ending in birth or egg hatching
GO:0010212 response to ionizing radiation
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143514
View Gene Order
ENSBTAG00000012781
Not yet available
Cross-References
SwissProt Q8CG79
TrEMBL E9QJU8 Q3UZC5
UniProt Splice Variant
Entrez Gene 209456
UniGene Mm.287450 Mm.406596
RefSeq NM_173378
OMIM
CCDS CCDS48476
HPRD
IMGT
MGI ID MGI:2138319
MGI Symbol Trp53bp2
EMBL AC131742 AK133930 AK134556 BC030894 BC042874 CB248714
GenPept AAH30894 BAE21932 BAE22185
RNA Seq Atlas 209456

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca